慢性乙肝患者血清no与肝纤维化关系探讨..doc

慢性乙肝患者血清NO与肝纤维化关系探讨        [07-11-0111:18:00]    作者:邹享珍    编辑:studa20【摘要】  目的:研究慢性乙肝患者(CHB)血清一氧化氮(NO)、透明质酸(HA)、层粘蛋白(LA),IV型胶原(C-IV)血清水平的变化,探讨其在肝纤维化机制中的作用。方法:应用比色法、放免法测定107例CHB、20例健康***血清NO、HA、LN、C-IV水平。结果:CHB轻、中、重度及肝硬化患者血清NO水平均显著高于对照组(P<),并随着肝损害和肝纤维化程度的加重而升高,血清NO水平与血清HA、LN、C-IV水平呈相关(P<)。结论:NO不仅与肝损伤密切相关,而且与肝纤维化程度相关,NO参与病毒性肝炎及肝纤维化的病理过程,检测NO有助于判断慢性肝病肝纤维化的程度【关键词】 慢性肝炎乙型血清NO 肝纤维化 ResearchtheRelationofHepaticFibrosiswithSerumNOinPatientswithChronicHepatitisB Abstract:Objective:Todiscussthechangesofserumnitric(NO),hyalopasmacid(HA),laminin(LN)andcollagentypeIV(C-IV)levelonhepaticfibrosismechanismbystudyingtheminpatientswithchronichepatitisB(CHB).Method:TheconcentrationsofserumNO,HA,LN,C-:ThelevelsofserumNOinmildCHBgroupmoderateCHBgroup,severeCHBgroupandlivercirrhosis(LC)groupwerehighersignificantthanthatinthecontrol(p<),andchangewiththedegreeofhepaticinjuryandfibrosis,ThelevelofserumNOwaspositivecorrelatedwiththelevelsofserumHA,LNandC-IV(p<).Conclusion:SerumNOiscorrespondingwithnotonlyhepaticinjury,butalsowithhepaticfibrosisdegree,NOtakes,NOtakespartinpathologicalprocessofviralhepatitisandhepaticfibrosisTestingtheserumNOcontributestoevaluatingthehepaticfibrosisdegreeinpatientswithchronichepaticdisease Keywords: ChronichepatitisB; SerumNO; Hepaticfibrosis       一氧化氮(NO)作为一种重要的细胞间信息分