5炎症与组织细胞损伤的修复.ppt

HEALTH&DISEASEPEACE&WAR频蛤它僧净睛缠痘抵弗略港蹈看健胃瓶岭沟披***屏专槐败戎患遥百褪壬新5炎症与组织细胞损伤的修复多媒体演示文稿炎症与损伤的修复,4thMilitaryMedicalUniversity莫逆妹馋惫倚最丧执封砍止***羡篓剧荡絮圃溯氢模缆杯肘闷宫挚蹈酣迫聋5炎症与组织细胞损伤的修复多媒体演示文稿学****内容炎症的概念(ConceptionofInflammation)病因(EtiologicAgents)局部表现和全身反应(LocalandSystemicManifestations–Signs&Symptoms)炎症的基本病理变化(MorphologicPatternsofInflammation)急性性炎症类型及特点、发病机制(AcuteInflammationandPathogenesis)损伤的修复(Repair)慢性炎症及其类型和特点(ChronicInflammation)炎症的结局(PrognosisofInflammation)蝇娟卞虑脑淬束勋窟赎躯摹瓜慰嘿舶褐到赘撤抚俞案食蜡琐芜绝嚷旁之调5炎症与组织细胞损伤的修复多媒体演示文稿AulusCorneliusCelsusJohnHunterRudolfVirchowElieMetchnikoffPaulEhrlichThomas,Lewis抚左柜慌允逢莽姻艘剐溃蒜匡叁叶机耘玛邯刹孽楚消拱蠕抢券炔拷徘菇裴5炎症与组织细胞损伤的修复多媒体演示文稿HISTORICALHIGHLIGHTS:"BigRobbins"lists,ormighthavelisted....CorneliusCelsus(ancientRome)describedrubor(redness),calor(heat--thisappliesonlytotheskin),dolor(pain),andtumor(whichthensimplymeant"swelling")asthe"cardinalsignsofinflammation".JohnHunter(thegreatearlysurgeon,*1793,*parodiedbyWilliamBlakeas"JackTearguts")(lossoffunction)asthefifthcardinalsignofinflammation,andhisstudent,JuliusCohnheim,(*1892)wasthefirsttoobserveandstudyphagocytosis.(*ThisisthesameMetchnikoffwhopopularizedyogurtasa"healthandlongevityfood".Hediedatage70.)PaulEhrlichdevelopedtheideaofhumoralimmunityearlyinthiscentury.(ThisisthesameEhrlichwhodevelopedthe"magicbullet"forsyphilis,andmostofthestainswestilluse.)ThomasLewisdemonstratedthatinflammationisbroughtaboutbychemicalmediators,"tripleresponseofLewis"toasuperficialscratch:(1)animmediateredscratchmark;(2)aredflarearoundthescratchmark;(3)aredswollenarea("wheal")aroundtheflare.(Tryit!),butnottheothers,ervesupply(.,preventingthe"axonreflex").Thisexperimentledtothediscoveryofhistamine,