奎硫平与奋乃静治疗老年精神障碍对照研究.doc

奎硫平与奋乃静治疗老年精神障碍对照研究.doc奎硫平与奋乃静治疗老年精神障碍对照研究【摘要】目的探讨奎硫平治疗老年精神障碍的临床疗效及安全性。方法将58例老年精神障碍患者随机分为两组各29例,分别口服奎硫平与奋乃静治疗,观察6w。于治疗前及治疗第2w、4w、6w末采用阳性与阴性症状量表评定临床疗效,副反应量表评定不良反应。结果治疗6w末,%,%;%,%;两组显效率、有效率比较均无显著性差异(P〉0・05)。阳性与阴性症状量表评分,两组治疗2w末起,总分及各因子分均较治疗前有显著下降(),同期两组间比较均无显著性差异(P>)o两组不良反应多在用药早期出现,程度较轻微,患者可耐受,经相应处理可减轻或缓解。奎硫平组完全依从率(%)高于奋乃静组(%),但差异无显著性(x2=,P>)。结论奎硫平治疗老年精神障碍疗效与奋乃静相当,且安全性高、服药依从性好,可作为治疗老年期精神障碍的首选药物。【关键词】老年;精神障碍;奎硫平;奋乃静Acontrolstudyofquetiapineandperphenazineinsenilementaldisorders[Abstract]ObjectiveToexploretheefficacyandsafetyofquetiapineinsenilementaldisorders・Methods58senilepatientswererandomlydividedintoquetiapineandperphenazinegroup(eachn=29)for6weeks・EfficacieswereassessedwiththePositiveandNegativeSyndrome(PANSS)andadveresereactionswithTreatmentEmergentSymptomScale(TESS)beforetreatmentandattheendsofthe2nd,,%%inthequetiapineand6&9%%intheperphenazinegrouprespectively,whichshowednosignificantdifferences(P>)・paredwithpretreatment(P&It;・01)parisons(P>)・urredearly,weremiIdandtolerable,andlessenedandrelievedfollowingcorrespondingtreatment・plianceratewashigherofquetiapine(%)thanofperphenazine(%)group,butthedifferencewasnotsignificant(P>)・ConelusionQuetiapinehastherapeuticequivalnecetoperphenazine,plianceinsenilemen