exposure to anic arsenic metabolites during early human….pptx

EOH:2504 Principles of Environmental ExposureInstructor: Dr. VolzYi-Han Huang EOH MPH to anic Arsenic Metabolites during Early Human Developmentby Gabriela Concha, Gerardo Vogler, Dora Lezcano, BarbroNermell, and Marie Vahter?Introduction?Material and Method?Results?ConclusionOutlineIntroduction?Why anic arsenic??Arsenic exposure via drinking water has been associated with cancer of the skin and various ans.?High doses of arsenite or arsenate to rodents prior to or anogenesis results in multiple malformations, decrease prenatal growth rate, and increased mortality. Introduction?Why prenatal??In a couple of studies, prenatal exposure to acute and very high dose of arsenic has resulted in miscarriage and early neonatal death.?Malformations, spontaneous abortions, and low birth weights has been observed among children of female employees in a copper smelter, but due to the multiple chemical exposure the role of arsenic is not ?There are a few reports indicating associations between adverse reproductive e and exposure to arsenic in drinking water, however, the causal relationship is not well ascertained.?In women without known exposure to arsenic, the concentration of arsenic in cord blood was similar to that in maternal blood (Kagey et al., 1977), however, the form of arsenic in blood was not determined.?The main exposure form of arsenic in blood is arsenobetaine, which can be present in high concentration in ?We have recently reported on high concentrations of arsenic in blood and urine of native Andean women and children living in an area in Northern Argentina with about 200 μgAs/liter in the drinking water.?The aim of the study was to investigate exposure to arsenic during early development paring concentrations and patterns of arsenic metabolites in cord blood and infant urine with those of maternal blood and and methods?Location?San Antonio de los Cobres, in the western part