R7与喉癌的淋巴转移.doc

R7与喉癌的淋巴转移        【摘要】  目的通过检测喉鳞状细胞癌(,简称喉鳞癌)R7)的表达,并探讨其与喉癌淋巴结转移的关系。方法选取40例喉鳞状细胞癌的存档蜡块为实验组,40例癌旁正常喉黏膜组织(距癌组织5mm以上经病理证实为正常喉黏膜)及20例经病理检查证实为喉良性病变组织声带息肉为对照组。R7的表达,并结合临床病历资料进行统计学分析,R7与喉癌临床病理特征的关系。R7的表达水平显着高于对照组(P<),而且在淋巴结转移组阳性率及表达强度均高于无淋巴结转移组,差异显着(P<)。R7与喉癌的淋巴结转移密切相关,而与喉癌患者的性别、年龄、是否吸烟、病理分级及临床分型无关。【关键词】 R7;喉癌;淋巴结转移 AbstractObjectiveTodetecttheexpressionof chemokinereceptor7(CR7) inlaryngealsquamouscarcinoma(LSC) casesofadjacentnormallaryngealmucosatissue(morethan5mmawayfromthecancerconfirmed pathologicallyasnormallaryngealmucosas)-binationwiththepathologicaldata,inquiringintotherelationshipbetweenCR7andVEGF--Cproteinshowedstrongpositiveexpressionin laryngocarcinoma,andtheexpressionofthemwassignificantlyhigherthaninthecontrolgroup(P<).Alsothepositiverateandstainingintensitywerehigherinthelymphaticmetastasisgroupthaninthenon-lymphaticmetastasisgroup,whichshowedasignificantdifference(P<).ConclusionsTheexpressionofCR7andVEGF-Carecloselyrelatedtolaryngocarcinomatouslymphaticmetastasisbuthasnorelationshiptothesex,ageandsmokingofapatientwithlaryngocarcino