SUPPLEMENTARY FIGURES.doc

SUPPLEMENTARYFIGURESPHOSPHORYLATEDHISTONE3ATSERINE10IDENTIFIESACTIVATEDSPINALNEURONSANDCONTRIBUTESTOTHEDEVELOPMENTOFTISSUEINJURY-ASSOCIATEDPAINJoseVicenteTorres-Pérez1,PéterSántha2,AngelikaVarga3,4,PeterSzucs3,4,JoaoSousa-Valente1;BotondGaal4,MiklósSivadó3,AnnaPAndreou1,SaraBeattie1,BenceNagy5,KlaraMatesz4,,GáborJancsó2andIstvanNagy1$1NociceptionGroup,SectionofAnaesthetics,PainMedicineandIntensiveCare,DepartmentofSurgeryandCancer,ImperialCollegeLondon,London,SW109NH,UnitedKingdom;2DepartmentofPhysiology,UniversityofSzeged,Szeged,H-6720,Hungary;3MTA-DE-NAPB-PainControlResearchGroup,DepartmentofAnatomy,HistologyandEmbryologyandDepartmentofPhysiology,UniversityofDebrecen,Debrecen,H-4012,Hungary;4DepartmentofAnatomy,HistologyandEmbryology,UniversityofDebrecen,Debrecen,H-4012,Hungary;5TheIpswichHospital,Ipswich,IP45PD,UnitedKingdom;6DivisionofCellSignallingandImmunology,CollegeofLifeSciences,SirJamesBlackCentre,UniversityofDundee,DundeeDD15EH,UnitedKingdomRunningtitle:p-S10H3inspinalnociceptiveprocessingSupplementaryFigure1Numberofp-S10H3immunopositvenucleiincontralateralsideofthesuperficialspinaldorsalhornofnaive(naive),sham-injured(sham),andburn-injuredrats5minutes(5’),30minutes(30’)and60minutes(60’)-regulationofp-(A)Animageofasectioncutfromtheipsil