Asymmetric Reduction of Heteroaryl Methyl Ketones Using iDaucus carotai.pdf.pdf

Green and Sustainable Chemistry, 2011, 1, 117-122 doi:.14019 Published Online November 2011 (rnal/gsc) Copyright ? 2011 SciRes. GSCAsymmetric Reduction of Heteroaryl Methyl Ketones Using Daucus carotaCh Sree Lakshmi, Goka Roopa Reddy, Adari Bhaskar anic Chemistry Division, Indian Institute of Chemical Technology, Hyderabad, India E-mail:*******@ Received July 7, 2011; revised August 26, 2011; accepted September 13, 2011Abstract Asymmetric reduction of the heteroaryl prochiral ketones to corresponding chiral alcohols by Daucus carota was studied. The study highlights selective bioreduction of different substituted heteroaryl ketones (1a - 1j) to their respective chiral alcohols (2a - 2j) using plant dehydrogenase enzymes present in Daucus carota ingood yields (60% - 95%) and enantioselectivity (76% - 99%) with S-form configuration. The results obtained confirm that the membrane bound dehydrogenase enzyme has broad substrate specificity and selectivity in catalyzing both six and five membered heteroaryl methyl present methodology demonstrates promising and alternative green route in the synthesis secondary chiral alcohols of biologically importance in a simple, inexpensive and eco-friendly process. Keywords:Daucus carota, Bio-Reduction, Chiral Alcohols, En