Alzheimer’s Disease and it’s Treatment - Web ….ppt

Presented by Kirmal MasihMedicinal ChemistryMarch 25th?Alzheimer's disease (AD), also known as Senile Dementia ofthe Alzheimer Type (SDAT) or simply Alzheimer’s is the mon form of dementia. This incurable, degenerative, terminal disease was first described by a German psychiatrist and neuropathologist Alois Alzheimer in 1906 and was named after him.?Alzheimer's disease (AD) is a slowly progressive disease of the brain that is characterized by impairment of memory and eventually by disturbances in reasoning, planning, language, and perception. ?Many scientists believe that Alzheimer's disease results from an increase in the production or accumulation of a specific protein (beta-amyloid protein) in the brain that leads to nerve cell death.?Generally, it is diagnosed in people over 65years of age, although the less-prevalent early onset of Alzheimer’s can occur much earlier.?In 2006, there were million sufferers worldwide.?Alzheimer’s is predicted to affect 1 in 85 people globally by ) Early Stage?This is considered as a mild/early stage and the duration period is 2-4 years.?Frequent recent memory loss, particularly of recent conversations and events.?Repeated questions, some problems expressing and understanding language.?Writing and using objects e difficult and depression and apathy can occur.?Drastic personality changes may pany functional decline.?Need reminders for daily activities and difficulties with sequencing impact driving early in this stage. 2) Second stage?This is considered as a middle/moderate stage and the duration is 2-10 years.?Can no longer cover up problems.?Pervasive and persistent memory loss impacts life across settings.?Rambling speech, unusual reasoning, confusion about current events, time, and place.?Potential to e lost in familiar settings, sleep disturbances, and mood or behavioral symptoms accelerate.?Nearly 80% of patients exhibit emotional and behavioral problems which are aggravated by stress and change.?Slowness, rigidity,