Immunology and Cancer - Syracuse University.ppt

Immunology and CancerFolder Title: CxImmuno(NoTP)andSome Concepts on Non-Immunological Host-Response in CancerUpdated: April 13, 2013TtlCxImmFigure The Biology of Cancer (? Garland Science 2007) p. ination of Mice with Irradiated Killed Tumor CellsImmune Response in it works, what does it “See”? target or targets does it attack? “weapons” does it attack with? do some tumors regress? doesn’t the immune response work better in cancers? the immune response in cancer make the pathology worse? can we make the immune response works better in cancer?Specific Adaptive Immune Responses:Humoral:Antibody-Antigen(Uses Antibodies to recognize Targets)Cell-Mediated:Helper and Cytotoxic T-Cells(Uses T-Cell Receptors to Recognize Targets)Anti-Cancer Effector MechanismsHumoral:Antibody plementLymphokines and other cytokinesCell-Mediated Immunity:Cytotoxic T-CellsNatural Killer Cells (NK Cells)Activated Killer CellsActivated macrophagesLymphokine-activated bined Humoral and Cell-mediated:Antibody-dependent Cell-mediated Cytotoxicity