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如何给予化学治疗药物.ppt
文档介绍:
reatmentofCancerClinicaloncologistSurgeonRadiationoncologistPathologistRadiologistTheDescriptionofCancerPatients1.Thepatternofpresentingsymptomsandsigns.2.Theevidenceofdiagnosis.3.Thediseaseextent.4.Thetreatmentplan.5.Theeffectsandsideeffectsoftreatments.6.Theongoingproblems.PathophysiologyofCancerLocaleffects:1.Tumornecrosis,infection,bleeding.2.Tumorinvasionofadjacentstructure.PathophysiologyofCancerRemoteeffects:1.Tumorproduction:hormones,growthfactors,cytokines,otherpeptides.2.Tumor-evokedproduction:a.Immunecells:antibodies,plex.b.Non-immunecells:otherpeptides.如何給予化學治療***物DNAsynthesisAntimetabolitesDNADNAtranscriptionDNAduplicationMitosisAlkylatingagentsSpindlepoisonsIntercalatingagentsCellularlevelActionsitesofcytotoxicagents6-MERCAPTOPURINE6-THIOGUANINEMETHOTREXATE5-FLUOROURACILHYDROXYUREACYTARABINEPURINESYNTHESISPYRIMIDINESYNTHESISRIBONUCLEOTIDESDEOXYRIBONUCLEOTIDESDNARNAPROTEINSMICROTUBULESENZYMESL-ASPARAGINASEVINCAALKALOIDSTAXOIDSALKYLATINGAGENTSANTIBIOTICSETOPOSIDEActionsitesofcytotoxicagents化學治療可以延長轉移患者的存活期***@Primarychemotherapy減輕癌症引起的不適***@Palliativechemotherapy增加手術或放射治療的療效***@Neoadjuvant&******@mitentradiosensitizer改善臨床的治療方式化學***物的給***靜脈注射:大多數***物長期低劑量灌注短期靜脈輸注靜脈推注口服***物:VP-16,UFT,Xeloda,Hydroxyurea,6-MP,6-TG 内容来自淘豆网www.taodocs.com转载请标明出处.