特发性中枢性性早熟和特发性矮小女孩初潮后治疗方法与疗效.doc

特发性中枢性性早熟和特发性矮小女孩初潮后治疗方法与疗效.doc特发性中枢性性早熟和特发性矮小女孩初潮后治疗方法与疗效比较崔朝晖王继东无锡市儿童医院江苏无锡214023)摘要:【目的】观察促性腺激素释放激素类似物(GnRHa)联合应用重组人生长激素(rhGH)治疗特发性屮枢性性早熟(ICPP)和特发性矮小(ISS)女孩月经初潮后预测成年身高(PAH)的效果。【方法】5例ICPP女孩和7例ISS女孩分别联合应用GnRHa(80—100mg・Kg",每隔28-32天肌肉注射一次),rhGH(・Kg」・『),连续应用18个月,对其治疗前后的生长速度,按骨龄的身高标准差分值(HtSDSBA)以及PAH进行分析。【结果】联合应用后二组女孩生长速度明显加快,HtSDSBA增加,|(|JPAH则明显延长,但两组之间的差并不明显。【结论】GnRHa联合应用rhGH能明显加快这二组患儿的生长速度,促进身高年龄对骨龄的追赶以及改善预测成年的身高。【关键词】月经初潮;性早熟;特发性矮小;促性腺激索释放激索;--huiWuxichildren7shospitalWuxiJiangsu214023ChinaAbstract:[Objective]binedtreatmentwithgonadotropin-releasinghormoneanalog(GnRHa)binanthumangrowthhormone(rhGH)onpredictedadultheight(PAH)ingirlswithcentralprecociouspuberty(CPP)andwithidiopathicshortstature(ISS)respectively.[Method]fivegirlswithCPP,sevengirlswithISSweretreatmentedatGnRHa80-lOOmgeKg"1every28to32days,•Kg-1*d'1,parisonsofgrowthvelocity,hightSDSforbongage(HtSDSBA)binedtreatmentat12monthsand18monthsrespectively.[Results]binedwithrhGHtherapygrowthvelocityincreasedsignificantly(P<),HtSDSBAincreasedandPAHprolongedsignificantly(P<)・【Conclusion】binedGnRHaandrhGHtreatmentcanremarkablyimprovegrowthvelocity,HtSDSBAandPAHinCPPandISSgirls.【Keywords]menophania;precocious;idiopathicshortsta