埃罗替尼联合GP方案治疗晚期非小细胞肺癌的临床疗效分析.doc

埃罗替尼联合GP方案治疗晚期非小细胞肺癌的临床疗效分析.doc埃罗替尼联合GP方案治疗晚期非小细胞肺癌的临床疗效分析张琳琳(辽宁省肿瘤医院内五科辽宁沈阳110042)【摘要】日的:探讨埃罗替尼联合盐酸吉西他滨及顺钳(GP)化疗对晚期非小细胞肺癌的临床疗效。方法:随机抽取采用GP方案化疗的Illb-IV期非小细胞肺癌患者90人,其中单纯GP方案化疗45人,埃罗替尼联合GP化疗45人。对患者生存率、病情缓解情况和血清中VEGF浓度进行观察分析。结果:%,%(P<)。%,%,差异有统计学意义(P<),(P<)。结论:埃罗替尼联合GP化疗较单纯GP方案治疗晚期非小细胞肺癌具有更显著的疗效,可以显著的提高患者的存活率和降低VEGF水平。【关键词】晚期非小细胞肺癌;埃罗替尼;疗效评价;盐酸吉西他滨;顺钳【 【文献标识码1B 【文章编号11003-5028(2015)8-0721-binedwithGPchemotherapyintreatmentofadvaneednon-smallcellIungcancer[Abstract]Objective:Toexplorethecurativeeffectoftreatingadvancednon-binationwithgemcitabinehydrochlorideandcisplatin(GP):Extracted90patientswhowereintheperiodoflllb-IVnon-smallcellIungcancerandusedGPprogramofchemotherapyrandomly,binedGPchemotherapy・Recordedthediseaseremission,survivalandserumVEGFlevelchangesofpatientswhowerebeforetreatmentandaftertreatmentrespectively,:Aftertreatment,binationgroups(%)increasedsignificantlythansimpleGPsolutionsgroup(%)(P<).binationgroups(%)increasedsign讦icantlythansimpleGPsolutionsgroup(%)(P<).binationgroups()decreasedsignificantlythansimpleGPsolutionsgroup()(P<).Conclusion:paredwithsimpleGPregimeninthetreatmentofadvaneednonsmallcellIungcancerandcansignificantl