寒冷损伤综合征.ppt

新生儿寒冷损伤综合征Neonatalcoldinjurysyndrome目的要求Tobefamiliarwithetiology、mechanismandpreventionTomastertheclinicalmanifestationandtreatmentsummary(概述)Neonatalcoldinjuryisadisorder,whichisduetocoldness(寒冷),prematurebirth(早产),infection(感染)andasphyxia(窒息).Theclinicalmanifestationsarehypothermia(低温)associatedwithlethargy(嗜睡),edema(水肿)andsclerema(硬化)oftheskin,.  内因(Intrinsicfactors)1)温度调节中枢(enter)发育不成熟2)散热过多(excessiveheatloss)3)体内储存热量少4)棕色脂肪(brownfat)的化学产热方式为主,缺乏寒颤等物理产热方式5)饱和脂肪酸(saturatedfattyacid)含量多,熔点高。(Extrinsicfactors)1)寒冷(coldness)2)摄入不足(intakedeficiency)3)早产(prematurebirth)4)疾病(diseases)①感染(infection)②窒息(asphyxia)3、多器官功能损害低体温、硬肿局部血液循环淤滞缺氧、酸中毒毛细血管↑多器官功能损害ClinicalManifestation 1、一般情况(Generalmanifestation) 少动(decreasedactivity)少哭少吃(poorfeeding)低体温(lowtemperature)2、皮肤表现(Skinfeature)1)硬化(cold,brightred,edemaandsclerema)2)顺序(gradation)小腿(calf)大腿(thigh)臀部9Buttock)面部(Face)上肢(upperlimb)全身(Totalbody)3)分度(Gradesofseverity)Accordingtoanareaofsclerema轻度(mild):<20%中度(moderate):20%~50%重度(severe):>50%3、多器官功能损伤循环衰竭(circulatorycollapse)急性肾功能衰竭(acuterenalfailure)肺出血(pulmonaryhemorrhage)呼吸衰竭(respiratoryfailure)DICPulmonaryhemorrhage(肺出血)