核医学科循环系统.ppt

循环系统
Cardiovascular System
心肌灌注显像
Myocardial perfusion imaging
原理
静脉注射的心肌灌注显像剂,或通过钠-钾-ATP的主动转运,如 201Tl,或通过单纯的跨膜弥散,如99mTc-MIBI,被正常心肌细胞摄取。局部心肌细胞摄取显像剂的多少与局部心肌血流灌注量呈正相关,通过显像观察局部心肌放射性分布和运动的变化,可对心肌的血流、功能、室壁运动、活力等进行评价。
Thallium is actively transported into myocardial tissue by the sodium-potassium adenosine triphosphate system (Na+-K+ ATPase). 99mTc-MIBI (hexakis-2-methoxyisobutylisonitrile) is a lipophilic pound. The initial myocardial distribution of thallium and 99mTc-MIBI are proportional to myocardial blood flow. So perfusion imaging is usually employed to detect the presence of myocardial ischemia and determine its location and extent.
显像剂
SPECT
201Tl(铊)
99mTc-MIBI(甲氧基异丁基异腈)
99mTc-tetrofosmin
99mTc-teboroxime
PET
13N-NH3
显像方法(imaging Procedure)

静息与负荷
运动负荷(exercise stress)
药物负荷(pharmacologic stress)
介入试验(intervetional test)

平面(planar imaging)与断层(SPECT imaging)
门控(gated imaging)
与非门控(non-gated imaging)
适应证





和疗效评价



图像处理和分析
正常图像
平面图像
正常图像
断层图像