fe-%2c3-o-%2c4-磁性纳米颗粒及其相关结构材料调控制备.pdf

东南大学硕士学位论文摘要本论文的研究背景是肿瘤磁过热治疗中磁性材料的制备。这需要材料具有良好的生物相容性, 因此选择生物毒性较低的Fe。0。材料比较合理的;同时材料的磁热转化性能将会直接影响治疗的效果,需要对制备的材料进行调控。因此实现Fe。0一颗粒的调控制备及发展与其相关的一些纳米结构材料对肿瘤磁过热治疗的研究将会是一个良好的支撑作用。首先用溶胶一凝胶法制备Fe。0。磁性纳米颗粒。论文中讨论了该方法制备Fe。0。磁性颗粒时不同起始条件对制备得到产物的影响,发现可以制备粒径在40姗~1200 nIIl范围内的Fe。0。磁颗粒,从而实现了不同粒径大小的铁氧体颗粒的可控性制备。用x-射线衍射(xRD)、x一透射电子显微镜(TEM)、电子衍射(ED)对不同大小的颗粒进行了结构和形貌的表征,此外还运用了振动样品磁强计(VSM)对其进行磁学特性测量。结果表明:这种方法能够制备不同粒径的立方尖晶石结构的Fe。0。磁性颗粒, 并且粒径不同的Fe。0。磁性颗粒形貌、磁性均有所不同。此外,我们还通过I(N0。氧化Fe(0H)。凝胶法制备Fe。0。过程中外加不同强度的磁场成功实现了产物Fe。0a磁性颗粒以及颗粒链的尺寸调控、形貌调控与链长的调控。对Fe。0。磁性颗粒链的磁学性质表征显示了一维有序结构的磁学各向异性,对该性质起因进行的分析表明是形状各向异性与链中颗粒的多畴结构共同作用的结果。最后,通过在制备Fe。Ot颗粒的过程中加入L一谷氨酸成功地制备了Fe。Oa空心球,并且在磁场的诱导下,能够制备出Fe。0。空心球一维的链状结构材料。对Fe。O。空心球及其一维结构材料进行了TEM、 SEM、xRD、IR及VSM表征分析,通过对表面形貌、官能团信息和磁学特性的分析,有助于更好地研究其生长机理。关键词:溶胶一凝胶法,四氧化三铁,磁性颗粒,一维结构,空心微球第1页东南大学硕士学位论文 Abstract The research background ofthis paper isbased on the preparation ic materials for tumour therapy ic fluid hyperthermia(MFH).The materials inthis application are required to be patible, of which the Fe304with low biotoxicity are rational candidates. At the same time, the heating ability of the iron oxide nanoparticles isdue to the synthesis route and is directly related with the efficiency of the therapy. So a tunable synthesis route of related iron oxide nanoparticles is necessary. Further, a research of the tunable synthesis and the development ofrelated iron oxide nanoparticles are of importance to the research of MFH therapy Firstly, we haVe prepared ite nanoparticles bysol—gel inthis paper, we will talk about the influence of the different original concentration of the solution on the production. We found that using this method we could prepare the ite nanoparticles with different diameters from 40nm to 1200nm. The obtained samples were characterized by Transmission Electron Microscopy(TEM)and X—Ray Powder Diffraction(XRD) in structure and appearance,and byVibrating Sample meter(VSM)in data show that we can use this method to fabricate the particles which