phythophera+α1性信息素合成的研究.pdf

上海师范人学硕+学何论文摘要昆虫性信息素是生物体个体分泌到外界,被同样的另外个体接受,能引起特定行为或发育反应的微量化学物质。Phytophthora(疫霉菌)是一类属于卵藻类生物的非真菌类植物病原体,可在世界范围类大面积的毁坏一些重要的农作物。其***素Phythophera al(3,7,11,15)-四***4羰基-(1,11,16)一三醇含有四个手性***,绝对构型并未确定,因此在本文中拟合成出其绝对构型。手性源(R).3.***-***己内酯都为工业废弃物,是我们小组罩已有的原料。选定(3R,7S,11R,15R)一Phythophera al为合成目标,以(R)-3-***吖. 丁内酯为起始原料,合成片段04和片段10,片段04和10通过亲核加成生成片段11,为Phythophera al性信息素的CI~C8片段;再以3一羟基-5-***己内酯为起始原料合成片段35,以商品化试剂3.***.,片段35和38连结合成Phytophthora al性信息素C旷C16片段40。片段11、40即为Phytophthora性信息素(3R,7S,l 1R,15R)·四***-4-羰基-(1,11,16)-三醇的主要片段。关键词:Ph”hophera al性信息素(R)-3.***.***己内酯上海师范大学硕十学位论文 Abstract Insect SeX pheromones aledesigned asthe trace ofchemical substance which ale excreted by insectand influences thebehavior ordevelopment ofothers ofthesame species. Phytophthora(Phytophthora sojae)is a class of non—egg algae fungus pathogens,Can induce important large-scale destruction ofcrops world· 聊thophera al(3,7,11,15)-tetramethyl一4-OXO一(1,11,16)-triol with four chiral methyl,the absoluteconfiguration was notdetermined,SO absoluteconfiguration would besynthesizedand textthebiological activity (R)一3一 methyl-),一butyrolactone and3-hydroxy-5-methyl caprolactone are industrial waste, asthe (3R,7s,1 R,15固一Phythophera a tosynthesize, (R)一3-methyl一),-butyrolactone asthestarting materialsynthetic fragment 04and fragment 0,fragment 04,and 0fragments generated bynucleophilic addition of forthePhytophthora homone’S leftfragment;again with3-hydroxy-5一methyl caprolactone syntheticfragment 35asthestartingmaterial,mercial reagent 3一 methyl-3一en-1一butanol synthesizedfragment 38,fragments of35and 38Synthesis ofPhytophthora link right half ofthehomone,the 39 1,39 shall Phytophthora homone(3R,7S,1 1R,15R)一4-methyl-4-OXO一(1,I l,16)一Calcitriol mainfragments. Key words:Phythophera homone al 僻)·3-methyl一丫一butyrolactone 3一 hydroxy·-5-·methyl caprolactone J::论文附录论文独创性声明本论文是我个人在导师指导下进行的研究工作及取得的研究成果。论文中除了特别加以标注和致谢的地方外,不包含其