clinical trials A practical guide to design analysis and reporting.pdf

Clinical Trials A Practical Guide to Design, Analysis, and Reporting Between the two countries of medicine and statistics is a stretch of land called clinical trials, where great treasures are to be found – the pearls of evidence-based medicine. In this no man’s land, a champion from each discipline fought and battled until they realized that they were both fighting on the same side. It was then that they joined forces and vowed allegiance to mon cause of demystifying the language of clinical trials. This jargon-busting book is the result of this unique collaboration between two experts in the fields of medicine and statistics. The authors have produced this ideal guide for anyone entering the world of clinical trials, whether to work there or just to pass through while reading journals or attending conferences. Indeed, absorbing some of the key chapters is an ideal initiation for anyone involved in writing, reading, or evaluating reports relating to clinical trials. This book is divided into five sections, covering issues that occur during all stages of clinical trials: ? Fundamentals of Trial Design ? Alternative Trial Designs ? Basics of Statistical Analysis ? Special Trial Issues in Data Analysis ? Reporting and Publication of Trials “This book covers an area that is rarely emphasized in a inct manner… deals with the basics, and provides the more interested reader with an in-depth understanding of the more subtle issues.” Salim Yusuf, MBBS, PhD – McMaster University “Essential for clinicians and researchers at all levels – demystifies clinical trials and biostatistics by providing clear relevant guidance.” Joseph Pergolizzi, MD – Johns Hopkins University 9 781901 346725 ISBN 1-901346-72-2 Clinical Trials A Practical Guide to Design, Analysis, and Reporting Duolao Wang, PhD Ameet Bakhai, MBBS, MRCP Duolao Wang, PhD Ameet Bakhai, MBBS, MRCP Statistician Cardiologist 14/11/05 12:51 Page 1 Author Biographies Duolao Wang, BSc, M