Gene set enrichment analysis A knowledge-based approach for interpreting genome-wide expression profiles_PNAS.pdf

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles Aravind Subramanian a,b, Pablo Tamayo a,b, Vamsi K. Mootha a,c, Sayan Mukherjee d, Benjamin L. Ebert a,e , Michael A. Gillette a,f, Amanda Paulovich g, Scott L. Pomeroy h, Todd R. Golub a,e, Eric S. Lander a,c,i,j,k , and Jill P. Mesirov a,k Broad Institute of Massachusetts Institute of Technology and Harvard, 320 Charles Street, Cambridge, MA 02141; Department of Systems Biology, Alpert 536, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02446; Institute for Genome Sciences and Policy, Center for Interdisciplinary Engineering, Medicine, and Applied Sciences, Duke University, 101 Science Drive, Durham, NC 27708; Department of Medical Oncology, Dana–Farber Cancer Institute, 44 Binney Street, Boston, MA 02115; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114; Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, C2-023, . Box 19024, Seattle, WA98109-1024; Department of Neurology, Enders 260, Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142; and Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142 Contributed by