光声成像技术简介课件 聂立铭.ppt

“”光声成像技术简介厦门大学分子影像暨转化医学研究中心聂立铭Email:******@xmu.•1901inPhysics:Roentgenfordiscoveryofx-raysin1895•1953inPhysics:Zernikeforinventionofphasecontrastopticalmicroscopy•1979inMedicine:CormackandHounsfieldforinventionofCTinearly1970s•2003inMedicine:LauterburandMansfieldforinventionofMRIinearly1970s•2008inChemistry:OsamuShimomura,•2014inChemistry:Eric Betzig,WilliamMoerner,andStefanHellforsuper-parisonofvariousimagingmodalities研究动机..Safety—Non-ionizingradiation:photonenergyis~..Physics—Relatedtothemolecularconformationoftissue...Optics—ontrast:..Opticalabsorption:Angiogenesis,hyper-metabolism,apoptosis,necrosis,andexogenouscontrastagents...Opticalscattering:Sizeofcellnuclei...Opticalpolarization:Collagen,musclefibers...研究动机Physiology—Functionalimagingofphysiologicalparameters:..Oxygensaturationofhemoglobin..Totalhemoglobinconcentration(relatedtobloodvolume)..Enlargementofcellnuclei..Orientationofcollagen..Denaturationofcollagen..Bloodflow(Doppler)Physiology—Molecularimaging(exogenouscontrastagents)...….-&2PMOCTDOT,PAT散射(扩散现象)限制弹道成像渗透到〜1mm的皮肤。被光声成像(PAT)克服实现超深度的高分辨成像。技术创新点UltrasoundtransducerstoreceivesignalsProducedultrasonicwaves(~mbar)Laserormicrowavepulse(ANSIlimit)’sPhotophone(历史)[1]AGBell,“Ontheproductionandreproductionofsoundbylight,”AmJScience20,305,1880[2]“Productionofsoundbyradiantenergy,”ManufacturerandBuilder13,156,1881Photoacousticeffect:LightabsorptionTemperatureriseThermoelastic