Lecture 7 Hydrogel Biomaterials Structure and Physical Chemistry.pdf
Molecular Principles of Biomaterials Spring 2003 Lecture 7: Hydrogel Biomaterials: Structure and Physical Chemistry Last Day: programmed/regulated/multifactor controlled release for drug delivery and tissue engineering Today: Applications of hydrogels in bioengineering Covalent hydrogels structure and chemistry of biomedical gels Thermodynamics of hydrogel swelling Reading: . Peppas et al., ‘Physicochemical foundations and structural design of hydrogels in medicine and biology,’ Annu. Rev. Biomed. Eng., 2, 9-29 (2000). Supplementary Reading: . Flory, ‘Principles of Polymer Chemistry,’ Cornell University Press, Ithaca, pp. 464- 469, pp. 576-581 (Statistical thermodynamics works work swelling) Applications of hydrogels in bioengineering • Hydrogels: work of polymer chains that swell in aqueous solutions • Gels can be classified by the type of crosslinker:1 • Covalent - covalent junctions • Physical - non-covalent junctions Lecture 7 – Hydrogels 1 1 of 15 Molecular Principles of Biomaterials Spring 2003 Physical gels: example- Hydrophobic interactions in physical gels water Physical gels are formed by noncovalent cross-links Example blocks: Poly(ethylene glycol) (PEG) Hydrophilic B blocks Hydrophobic A blocks Poly(propylene oxide) (PPO) Poly(butylene oxide) (PBO) • Key properties of gels for bioengineering applications: 1. in situ formability 2. degradability 3. responsive swelling 4. tissue-like structure/properties • In situ formability Gelation of liquid solutions by: • Irradiation with light • Temperature change (. 4°C to 37°C) • Cross-linking enzymes • Presence of divalent salts ON BOARD: In situ formation ¥h ν ¥Heat ¥Crosslinking by enzymes ¥Introduction of divalent cations (. Ca++, Mg++) Lecture 7 – Hydrogels 1 2 of 15 Molecular Principles of Biomaterials Spring 2003 Key propert
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