Drug Discovery and Genomics.ppt

Drug Discovery and Genomics
How the Sequencing of the Human Genome and Related Developments has Impacted Drug Discovery
B i o p h a r m a c e u t i c a l s L t d.
“Fortunes will be won and lost in the
genome grab. The race to secure the
sequence patents will be over in five
Years.”
The World in 2001. The New Economist on pharma-
ceuticals.
B i o p h a r m a c e u t i c a l s L t d.
The Promise
The Concern
The Human Genome Project and
related technologies has generated
thousands of novel potential drug targets.
Validating those targets and their
drugability and generating therapeutic
options are now the rate limiting
steps in drug development.
Bottom Line
B i o p h a r m a c e u t i c a l s L t d.
Topics
What is Genomics ?
What is the relationship between genes and disease?
What are the steps in developing a drug?
What impact has genomics had on the process of drug development?
B i o p h a r m a c e u t i c a l s L t d.
What is Genomics ?
Study of information stored in the genome
structural and functional information
Structural genomics — the sequence
Information is encoded linearly and digitally in four coding molecules-bases
Three bases = codon = amino acid
A number of codons strung together code for a gene which codes for a protein
Functional genomics — what the genes do
B i o p h a r m a c e u t i c a l s L t d.
B i o p h a r m a c e u t i c a l s L t d.
B i o p h a r m a c e u t i c a l s L t d.
Comparative Sequence Sizes
(Bases)
(yeast chromosome 3)
350 Thousand
Escherichia coli (bacterium) genome
Million
Largest yeast chromosome now mapped
Million
Entire yeast genome
15 Million
Smallest human chromosome (Y)
50 Million
Largest human chromosome (1)
250 Million
Entire human genome
3 Billion
Return to text
B i o p h a r m a c e u t i c a l s L t d.