系统性红斑狼疮与感染.pptx

LUPUS Vs INFECTION
Zhao jiuliang
Department of Rheumatology
PUMCH, Beijing
1
Q1. What are the most frequent infections in patients with SLE?
Q2 Which are the clinical factors involved in the development of infections in SLE?
Q3 How can the risk of infectious complications in SLE be reduced?
2
Q1. What are the most frequent infections in patients with SLE?
3
Infection is responsible for approximately 25% of all deaths in patients with systemic lupus erythematosus (SLE)
The main reason of hospitalization
Appears to be highest within the first 5 years of disease onset
4
Infection in SLE
Clin Rheumatol, 2014. 33(1): 57-63.
5
Characteristics of major infections in SLE
Respiratory tracts
Urinary tracts
Skin and soft tissues
The types of infections that SLE patients developed were the same as in the general population
6
The most frequent infections include:
Pneumonia, herpes zoster virus, and urinary tract infection
Arthritis Care Res (Hoboken), 2015. 67(8): 1078-85.
Characteristics of major infections in SLE
7
Relative risks of hospitalizations
Lupus compared with general population
Arthritis Care Res (Hoboken), 2015. 67(8): 1078-85.
8
Pathogen of infection in SLE
Gram-negative bacilli, gram-positive cocci, fungal and other bacterial infections accounted for %, %, % and %, respectively of nosocomial infections.
9
Clinical manifestations of infections
Atypical !!!
10