酸碱平衡紊乱595511188-课件（ppt·精·选）.ppt

酸碱平衡和酸碱平衡紊乱 Acid base balance and its disorder by Li ZHANG Pathophysiology Department pH Enzyme Activity Curve showing relationship between Enzyme Activity and pH 课程内容 Lecture Objectives ?酸和碱的定义 Explain the definition of acid and base ?两种酸 Introduce two types of acids ?机体对 pH 变化的代偿 pensation for pH shift ?实验室指标 Laboratory parameters ?四种单纯性酸碱紊乱 Four types of acid base disorders ?混合型酸碱紊乱 Mixed acid base disorders [H + ] (nmol/L) 100 805040362016 160 体液 Bodily Fluid pH ?血浆 Blood plasma ?唾液 Saliva - ?胃液 Gastric juice - ?尿液 Urine - ?肝细胞内液 Liver cytosol ?微粒体 Lysosomes < ?线粒体间质 Mitochondrial matrix - ?Most biochemical processes depend heavily on the pH of the solution. Thus partments of the body and its cells are maintained at optimum pHs for the relevant processes that occur there. ACIDS ? Acids can be defined as a proton ( H H + + ) donor ? Hydrogen containing substances which dissociate in solution to release H H + + Click Here ACIDS ? Acids can be defined as a proton ( H H + + ) donor ? Hydrogen containing substances which dissociate in solution to release H H + + Click Here ACIDS ? Acids can be defined as a proton ( H H + + ) donor ? Hydrogen containing substances which dissociate in solution to release H H + + H+ OH- H+ OH- H+ OH- H+ OH- ACIDS ? Many other substance (carbohydrates) also contain hydrogen but they are not classified as acids because the hydrogen is tightly bound within their molecular structure and it is never liberated as free H H + + H+ OH- H+ OH- H+ OH- H+ OH- 10 BASES