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pharmacokinetic assessment of alprazolam-induced neonatal abstinence syndrome using physiologically based pharmacokinetic model论文资料.pdf


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pharmacokinetic assessment of alprazolam-induced neonatal abstinence syndrome using physiologically based pharmacokinetic model论文资料.pdf
文档介绍:
Drug Metabolism and Pharmacokinetics 34 (2019) 400e402

Contents lists available at ScienceDirect

Drug Metabolism and Pharmacokinetics
journal homepage: http://www.journals.elsevier.com/drug-metabolism-and-
pharmacokinetics

Note
Pharmacokinetic assessment of alprazolam-induced neonatal
abstinence syndrome using physiologically based pharmacokinetic
model

*
Kazuhiro Yamamoto a, , Sachiyo Fukushima b, Yui Mishima a, Mari Hashimoto a,
Kei Yamakawa a, Kazumichi Fujioka b, Kazumoto Iijima b, Ikuko Yano a

a Department of Pharmacy, Kobe University Hospital, Kobe, Japan
b Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan

article info abstract

Article history: Sustained benzodiazepine use during pregnancy can induce neonatal abstinence syndrome (NAS). In this
Received 19 July 2019 study, the association between NAS and plasma alprazolam concentration was examined using the
Received in revised form measured neonatal concentrations in th
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