Determinants of Bone and Blood Lead Levels among Minorities Living in the Boston Area (Article begins on next page) The munity has made this article openly available. Please share how this access benefits you. Your story matters. Citation Lin, Charles, Rokho Kim, Shirng-Wern Tsaih, David Sparrow, and Howard Hu. 2004. Determinants of bone and blood lead levels among minorities living in the Boston area. Environmental Health Perspectives 112(11): 1147-1151. Published Version doi: Accessed June 1, 2016 2:25:31 PM EDT Citable Link -3::4728498 Terms of Use This article was downloaded from Harvard University's DASH repository, and is made available under the terms and conditions applicable to Other Posted Material, as set forth at -3::-of- use#LAA Research has suggested that lead toxicity may disproportionately affect minority groups. (Bailey et al. 1994; Rothenberg et al. 1999). Despite substantial declines in blood lead levels in the general . population, a sub- stantial body of research, including data from the Third National Health and Nutrition Examination Survey (NHANES III), shows that African Americans continue to have higher blood lead levels than do whites (Brody et al. 1994; Lanphear et al. 1996; Mahaffey et al. 1982; Pirkle et al. 1998). Most studies analyzing racial differences in lead toxicity have focused on blood lead as a biomarker. Although blood lead mostly provides an accurate measure of recent lead exposure, evidence has been growing to indicate that this biomarker does not ade- quately reflect an individual’s health risk due to cumulative lead exposure (Hu et al. 1998). In adults, about 95% of the total body lead burden is stored in the skeleton (Barry and Mossman 1970), and the half- life of lead in bone ranges from years to decades (Rabinowitz 1991). With a half-life of up to 25 years (Rabinowitz et al. 1976), bone lead is a biologic m