运用双向发酵技术建立中药微生物药代模型的设想.doc

运用双向发酵技术建立中药微生物药代模型的设想
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运用双向发酵技术建立中药微生物药代模型的设想--专题综述
摘要：简述传统中药药物代谢研究方法的现状与缺乏，指出利用微生物药代模型进展中药药代研究的技术优势，认为它为中药药物代谢研究提供了新的思路与方法。 通过对独特的“双向发酵〞技术实用意义及应用前景的深入分析，提出运用其建立中药微生物药代谢模型的设想。
关键词： 双向发酵；中药；药物代谢；微生物模型
运用双向发酵技术建立中药微生物药代模型的设想
Assumptions of Establishing the Microbial Models of Drug
Metabolism of Traditional Chinese Herbs by Applying Bi-Directional
Solid Fermentation Technology
PAN Yang， PENG Wei， LIU Chun-mei
〔Department of Bio -Pharmacy and Laboratory of Medical Fungi and Phyto -Biotech ，Nanjing University of
Chinese Medicine，Nanjing 210029，China〕
Abstract： In this manuscript，the progress and deficiency of drug metabolism of traditional Chinese
herbs were introduced. The technical advantages were pointed out that drug metabolism research
was performed by using the microbial models which provide a novel ways for Chinese herbs drug
metabolism. Based on the analysis of practical meaning and prospect of the special 'bi-directional
fermentation' technology，the assumption of establishing the microbial models of drug metabolism of
Chinese herbs was suggested by applying this technology.
Keywords： bi -directional fermentation，traditional Chinese herbs，drug metabolism，microbial
models
众所周知，中药是伴随着中华民族几千年的文
明史开展传承下来的珍贵财富。 目前，中医药在国
内虽然有着稳定的市场和生命力，但始终无法得到
现代世界医药主流的认可。 其原因主要是由于传统
中药缺乏可靠的药效学、药物代谢动力学和平安性
等一系列根底研究数据
[1]
，尤其是中药的药物代谢
〔简称中药药代 〕。 药物代谢是指药物在体内的吸
收、分布、代谢和排泄过程。 药物作为外来分子进入
貙貦貍Journal of Food Science and Biotechnology 2021
PAN Yang，et al： Assumptions of Establishing the Microbial Models of
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Drug Metabolism of Traditional Chinese Herbs by