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a 2-step mechanism of arterial thrombus formation induced by human atherosclerotic plaques外文参考.pdf


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a 2-step mechanism of arterial thrombus formation induced by human atherosclerotic plaques外文参考.pdf
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Journal of the American College of Cardiology Vol. 55, No. 11, 2010
© 2010 by the American College of Cardiology Foundation ISSN 0735-1097/10/$36.00
Published by Elsevier Inc. doi:10.1016/j.jacc.2009.11.051
A 2-Step Mechanism of Arterial Thrombus
Formation Induced by Human Atherosclerotic Plaques
Armin J. Reininger, MD, PHD,* Isabell Bernlochner, MD,† Sandra M. Penz, PHD,†
Catherine Ravanat, PHD,‡ Peter Smethurst, PHD,§ Richard W. Farndale, PHD,§
Christian Gachet, MD, PHD,‡ Richard Brandl, MD,ʈ Wolfgang Siess, MD†
Munich, Germany; Strasbourg, France; and Cambridge, United Kingdom
Objectives The aim of this study was to understand the initial mechanism of arterial thrombus formation induced by vulner-
able human atherosclerotic plaques to re-assess and improve current antithrombotic strategies.
Background Rupture of atherosclerotic plaques causes arterial thrombus formation that might lead to myocardial infarction and
ischemic stroke. Atherothrombosis is considered as an inseparable tangle of platelet activation and coagulation pro-
cesses, involving plaque components such as tissue factor (TF) and collagen as well as blood-borne TF and coagula-
tion factor XIIa (FXIIa). A combination of anticoagulants and antiplatelet agents is the present treatment.
Methods Human atheromatous plaque material was exposed to blood or blood components at physiological calcium/magne-
sium concentration. Platelet aggregation and coagulation were measured under s
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