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154A ABSTRACTS – Poster JACC February 1997
injury in normolipemic swine. Formalin fixed, paraffin embedded coronary cent reduction of electrolytic injury-induced’ femoral vein thrombosis. Theae
artery sections were stained using conventional ABC methodology and im- data indicate that DMP754 has a comparable intranaeal and intravenous an-
munoperoxidaae techniques. Human melanoma and normal kidney aerved tiplatelet and antithrombotic profile along with a significant improvement over
as positive controls. Deletion and substitution controls for primary antibody its oral antiplateletiantithrombotic profile. These data suggest the potential
were negative. Staining of contiguous sections with specific cell marker anti- utility of intranasal DMP754 in various acute and chronic thromboembolic
bodies identified SMC, EC, macrophages (MAC) and myofibroblasts (MYF). disorders.
UW%staining was ordinally graded from O (none) to 3 (strong). Resuk In
the uninjured coronav artery, only the Iuminal endothelium expressed a,&+
Marked temporal-spatial variation in expression was noted in all vessel 1960-113] Moaain:ACellMembrane Protein Reg