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secreted antigen receptors in cartilaginous fish开题资料.pdf


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secreted antigen receptors in cartilaginous fish开题资料.pdf
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82 Abstracts of the 7th Congress of the ISDCI: Plenary Lectures
Secreted Antigen Receptors in Cartilaginous Fiih
Martin Flajnik
Over the past six years we and others (primarily the labs of Litman, Marchalonis, and Tomanaga)
have examined the arsenal of secreted antigen receptors in elasmobranchs, with our major emphasis
on the nurse shark, Ginglymostoma cirratum. Here I discussthree aspects of these studies: 1) the
unexpected diversity of light (L) chains (1); 2) the discovery of a novel secreted molecule (2); and
3) the existence of an alternative form of NAR and &X(R), an isotype previously believed to be
limited to the skate (3).
While attempting to isolate shark T ceil receptor genes from the nurse shark by PCR with degenerate
primers, four cDNA products were obtained (none were T cell receptors!). One cDNA was shown
to be a novel L chain with unexpected high similarity in its variable (V) region to mammalian K L
chains. These results demonstrated that K-like chains emerged very early in the evolution of the
adaptive immune system and confirmed much earlier N-terminal sequencing work by Clem suggesting
that the major expressed nurse shark L chain was most similar to mammalian K (4). A second nurse
shark L chain (second PCR product analyzed) showed high similarity to.a sandbar shark L chain.
This high similarit
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