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Cytokine 127 (2020) 154996
Contents lists available at ScienceDirect
Cytokine
journal homepage:
Secreted protein acidic and rich in cysteine and cancer: A homeostatic
hormone? T
⁎
Abdelaziz Ghanemia,b, Mayumi Yoshiokaa, Jonny St-Amanda,b,
a Functional Genomics Laboratory, CREMI, Québec Genome Center, CHUL-CHU de Québec Research Center, Québec, Québec G1V 4G2, Canada
b Department of Molecular Medicine, Faculty of Medicine, Laval University, Québec, Québec G1V 0A6, Canada
ARTICLE INFO
Keywords:
Secreted protein acidic and rich in cysteine
Cancer
Hormone
Homeostasis
1. Introduction apoptosis, etc) and the metabolic patterns that are shaped in cancer
cells make SPARC (as a hormone) implications under carcinogenesis
The implications of the extracellular matrix (ECM) in cell develop- conditions worth exploring

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