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Journal of Saudi Chemical Society (2017) 21, 277–285
King Saud University
Journal of Saudi Chemical Society

ORIGINAL ARTICLE
Synthesis and biological evaluation of new
benzofuran carboxamide derivatives
Andiappan Lavanya a,b, Rajendran Sribalan b, Vediappen Padmini b,*
a Orchid Chemicals & Pharmaceuticals Ltd, R&D Centre, Chennai 600119, India
b Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625021, Tamil Nadu, India
Received 10 April 2015; revised 19 June 2015; accepted 26 June 2015
Available online 4 July 2015
KEYWORDS Abstract A series of new 3-(glycinamido)-benzofuran-2-carboxamide and 3-(b-alanamido)-benzo
Benzofuran; furan-2-carboxamide derivatives (5a–o) were synthesized for the purpose of developing the new
Carboxamide; bioactive chemical entities and evaluated for their in vitro antimicrobial, anti-inﬂammatory and
Glycinamide; DPPH radical scavenging activities. The synthesized compounds were characterized by NMR,
b-Alanamide; IR, Mass an

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