毒物的处置与毒代动力学 (2).ppt

毒物的处置与毒代动力学
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毒代动力学（Toxicokinetics ）
What is Toxicokinetics?
"how a substance gets into the body and what happens to it in the body"
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The term of toxicokinetics was originated from pharmacokinetics
The science of toxicology has evolved to include environmental and occupational chemicals as well as drugs
Toxicokinetics is thus the appropriate term for the study of the kinetics of all toxic substances
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毒代动力学
运用药物代谢动力学的原理和方法，定量地研究在毒性剂量下药物在动物体内的吸收、分布、代谢、排泄的过程和特点，进而探讨药物毒性的发生和发展规律的一门科学。
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Four processes are involved in toxicokinetics
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How toxicokinetics of a substance can influence its toxicity?
Why a substance of low toxicity may be more of a hazard than a highly-toxic substance?
Why two substances with equal toxicity and absorption may differ in hazard?
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