阿昔洛韦口腔缓释膜的制备及其体外释放.doc

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阿昔洛韦口腔缓释膜的制备及其体外释放 作者：糜志远 张迎庆 王忆娟 程 丽 来源：《中国医药导报》 2008 年第 23 期
［摘要］ 目的：以魔芋葡甘聚糖和黄原胶两种天然多糖为基质，制备新型阿昔洛韦口腔缓释 膜，用于疱疹性口腔溃疡局部给药。方法： 1%(W/W) 魔芋葡甘聚糖和 1%(W/W) 黄原胶溶液按 体积比7 : 3配制成混合凝胶 45 ml， ml甘油， ml吐温-80，再加入已溶解于 5 ml g,取30 ml胶液在5 cmX8 cm无菌玻璃槽中干燥成膜，制成直径为
cm 的膜片。通过紫外分光光度法进行阿昔洛韦含量和体外累积释放度测定。结果：所得药膜
的阿昔洛韦含量为( ±.34)mg/片，在30 min时体外累积释放度为 %， h时
达到最大释放,为 %。结论：魔芋葡甘聚糖和黄原胶复配凝胶基质的阿昔洛韦口腔膜 剂,具有较好的缓释效果,可望进一步深入开发。
［关键词 ］ 口腔缓释膜；阿昔洛韦；魔芋葡甘聚糖；黄原胶
［中图分类号 ］R944 ［文献标识码 ］A ［文章编号 ］1673-7210 (2008) 08(b) -025-03
Preparation and in vitro release of Aciclovir Oral Sustained Release Membrane
MI Zhi-yuan, ZHANG Ying-qing, WANG Yi-juan, CHENG Li
(Department of Pharmaceutics Engineering, Bioengineering College, Hubei University of Technology, Wuhan430068, China)
[Abstract] Objective: Konjac glucomannan and xanthan gum as matrix to prepare Aciclovir Oral Sustained Release Membrane for oral herpes ulcer treatment. Methods: 1% (W/W) of konjac glucomanan and 1% (W/W) of xanthan were mixed at the ratio of 7 : 3 (V/V) to form 45 ml of mixed
gel, ml of glycerin and ml of Tween-80 were added, g of aciclovir dissolved in 5 ml of water and also was added. 30 ml of mixed gel was pulled on the surface of a 5 cm 8 cm sterilized glass and dried to form membrane, the