DEPARTMENT OF IMMUNOLOGY
趋化因子及其受体
(Chemokines & Chemokines receptors)
Department of Immunology,Shanghai Medical College
Fudan University
******@
Cytokine
gene
Inducing stimulus
Cytokine-producing cell
Cytokine
Gene activation
Receptor
signal
Biological effects
Overview of the induction and function of Cytokine
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IL-33: a sheep in wolf's clothing?
Massimo Gadina
Email: .******@Address:Queen's University BelfastWhitla Medical Building97 Lisburn RoadBelfast BT9 7BL Telephone (work):+44 (0)28 9097 2206
Fig. 1. Model for the potential anti-inflammatory effects of IL- dual effects of IL-33 activity are depicted. The precursor form of IL-33 is processed in the cytoplasm, possibly by the activity of a multiprotein caspase-1–containing complex known as an inflammasome. Once released from the cell, IL-33 binds its receptor complex at the cell surface. This complex, which contains ST2 and (by analogy to other IL-1 receptor family members) an as-yet-unidentified accessory receptor recruits the TIR domain–containing adaptor MyD88 to its intracellular domain through a homotypic TIR-TIR interaction. Subsequent recruitment of the serine-threonine kinases IRAK1 and IRAK4 and
downstream activation of the E3 ligase TRAF6 are thought to drive NF-κB and MAPK activation and the subsequent production of the Th2-specific cytokines IL-4, IL-5, and IL-13. Unprocessed IL-33 accumulates in the nucleus, where it acts as a transcriptional repressor. NEMO, NF-κB essential modifier. SIGGR, single immunoglobulin IL-1R-related molecule.
趋化因子的结构与功能
一、 趋化因子概述
二、 趋化因子受体
三、 趋化因子的结构特点
四、 趋化因子的生物学作用
五、 某些应用
趋化因子的发现
趋化因子的共性
趋化因子的分类
趋 化 因 子 概 述
趋化因子的发现
起始期(80s中) 未形成概念 PF4
成熟期(80s后) 完整概念/分类 大量趋化因子
高潮期(90s中) 发现CCR5
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