Immuno-PET在程序性细胞死亡受体配体-1活体成像中的研究进展.pdf

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分子影像学杂志, 2021, 44(1): 193 197 doi .1674- ·193·
Immuno-PET 在程序性细胞死亡受体配体-1 活体成像中的研究
进展
肖庆澳，夏 旋
三峡大学医学院生理与病理生理系，湖北 宜昌 443002
摘要：免疫正电子发射计算机断层显像（Immuno-PET）是一种高效特异性，无创性和活体即时成像的诊断技术。这种技术不仅
能可视化活体肿瘤细胞的定位，并且可识别肿瘤免疫受体（如PD-L1）并进行分子量化。PD-L1的靶向成像和预后评价方面具
有巨大的发展前景。近年来，Immuno-PET在PD-L1靶向活体成像方面的研究逐渐成为热点。本文就Immuno-PET活体表征
PD-L1的原理、应用价值、常用核素、新型示踪剂性质以及其在活体动物、人体上的成像效果等方面作一综述。
关键词：免疫正电子发射计算机断层显像；程序性细胞死亡受体配体1；肿瘤免疫；活体分子成像；同位素示踪剂
Advances in vivo imaging of PD-L1 by Immuno-PET
XIAO Qing'ao, XIA Xuan
Department of Physiology and Pathophysiology, School of Medicine, China Three Gorges University, Yichang 443002, China
Abstract: Immuno-positron emission tomography (Immuno-PET) is high efficient, noninvasive technique to in vivo imaging.
This technique can not only visualize the tumor location, but also identify and quantify the changes of tumor immunological
receptor (such as PD-L1). It has a promising prospect in programmed death ligand 1 (PD-L1) targeted imaging and evaluation
on prognosis. In recent years, immuno-PET in PD-L1-targeted in vivo imaging becomes a hotspot in research. This review
would summarize the principle of various new PD-L1 probes, application, common nuclides, properties of novel m