甜菜碱的生理功能与药物活性.pdf

现代食品科技 Modern Food Science and Technology 2008, ,

甜菜碱的生理功能与药物活性

刘燕燕 1,曾新安 1,朱思明 1,孙卫东 2
(,广东广州 510640)(,广西南宁 530004)
摘要;综述了甜菜碱的生理功能和药物活性,包括甜菜碱作***供体参与蛋氨酸循环和作为渗透调节调节高渗状态下的细胞反
应,以及甜菜碱对心血管类、神经类、肝脏类和高半胱氨酸尿症类等疾病的药物活性。这为甜菜碱用作饲料添加剂和人类疾病治疗的
备选药物提供了依据,有助于甜菜碱应用范围的拓展。
关键词:甜菜碱;生理功能;药物活性
中图分类号:;文献标识码:A;文章篇号:1673-9078(2008)01-0096-05
Physiological Functions and Pharmacological Activities of Betaine
LIU Yan-yan, ZENG Xin-an, ZHU Si-ming, SUN Wei-dong
( of Light industry and Food science, South China University of Technology, Guanghzou 510640, China)
( of Sugar Science and Technology, Guangxi University, Nanning 510640, China)
Abstract: The physiological functions and pharmacological activities of betaine were reviewed in this paper. Betaine could be used as a
methyl donor for methionine metabolism and osmosis-regulator for cell response under hypertonic stress. It also showed pharmacological
activities towards the diseases of heart, nerve and liver, and hyperhemicysteinuria. The functions and activities of betaine provided a basis for the
application aine as vessel additives and human drug candidate.
Key words: betaine; physiological function; pharmacological activity

甜菜碱(三甲氨基乙内酯)分子式为(CH3)3N 甜菜碱有三个非稳态***,是有效的***供体。
CH2COO-,其结构式如图1所示,无强吸湿性,无毒, 在动物体内,甜菜碱、胆碱和蛋氨酸三者在体内可相
物化性质稳定,耐高