免疫学课件T cell developmentXuanming.pptx

(免疫学课件)T cell development_Xuanming
杨选明
特别研究员 生命科学技术学院(-)
******@
生命学院2-211（office） ；2-316（lab）
Tumor Immunology and Immunotherapy
DC
Tumor
NK
T
MDSC
TAM
Treg
Tumor killing
Tumor promotion
Investigate the mechanism of immune suppression and activation in tumor (tumor immunology);
Design modulatory tools to enhance tumor killing and reduce immune suppression, which will control tumor (immunotherapy);
Immune suppressive cell
Immune activating cell
Immune responses
Innate immunity
Adaptive immunity
kinetics
Targets
Memory
Immune responses
Innate immunity
Adaptive immunity
kinetics
Immediate responses,
Initiated within seconds
Gradual responses,
Generated over 3-4 days
Targets
Shared products from a group of pathogens
Specific products from specific pathogens
Memory
No
Yes. Respond to the same Ag faster and stronger.
Adaptive immune responses
B cell mediated immunity
T cell mediated immunity
Major player
Origin
Maturation
Memory
effector
Target
Adaptive immune responses
B cell mediated immunity
T cell mediated immunity
Major player
B cell
T cell
Origin
Bone marrow
Bone marrow
Maturation
Bone marrow/Bursa
Thymus
Memory
Yes
Yes
effector
Humoral (antibody)
Cellular ( not antibody)
Target
Non-MHC-restricted
MHC restricted
T cell
What is T cell?
Where and how it come from?
What is its function?
T cell development (May 10th);
Antigen presentation and T cell responses(May 13th );
T cell signaling(May 24th);
Questions for T cell development:
How do you characterize a T cell? Subtypes?
2. How do you coordinate lineage specification with MHC specificity and coreceptor expression?
•  vs.  T cell; CD4 vs CD8
3. How do you generate a T cell population that is self-MHC restricted?
4. How do you ensure that those diverse T cell receptors are not-self reactive?
5. How do you generate a diverse T cell populati