cocos nucifera and bination for modulation of diabetic symptoms in streptozotocin induced diabetic rats英文.pdf

Journal of Ayurveda and Integrative Medicine 11 (2020) 3e9
Contentreptozotocin (45 mg/kg; .).
Type 2 diabetes mellitus Plasma glucose level (PGL) was estimated after 72 h of STZ injection. Ethanolic extract of CnI (250 mg/kg
Combination therapy and 500 mg/kg) per se and in combination with metformin ( mg/kg) was administered orally once
Streptozotocin daily to rats for a period of 28 days. PGL level was estimated on 7th,14th and 21st day followed by Oral
Glucose Tolerance Test (OGTT) and PGL both on the 28th day of treatment. DPPH assay was performed to
evaluate antioxidant activity of CnI extract.
Results: Extract of CnI (250 mg/kg and 500 mg/kg alone and the combination of extract (250 mg/kg)
along with metformin ( mg/kg) significantly decreased PGL (p < ) on 7th,14th,21st and 28th
days. Histopathological analysis of pancreatic tissue showed that treatment with CnI extract per se and in
combination with metformin improved the damaged architecture of