combining functional and tubular damage biomarkers improves diagnostic precision for acute kidney injury after cardiac surgery外文参考.pdf

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY ,,2014
ratios (LR), and area under
the curve receiver operating curve (AUC-ROC) values.
RESULTS Severe AKI occurred in 18% of patients. The composite uNGALþ/pCysCþ demonstrated a greater likelihood
than DSCr for severe AKI (þLR: [:] vs. [:]) and persistent AKI (þLR: [:] versus
[:]). In AKI patients, the uNGALÀ/pCysCþ composite was superior to DSCr for prediction of transient AKI.
Biomarker composites carried greater probability for specific outcomes than DSCr strata.
CONCLUSIONS Composites of functional and tubular damage biomarkers are superior to DSCr for predicting discrete
characteristics of AKI. (J Am Coll Cardiol 2014;64:2753–62) © 2014 by the American College of Cardiology Foundation.
ver the past 2 decades, the incidence of (1–4). Because no singular therapy has demonstrated
O acute kidney injury (AKI) has grown expo- efficacy for mitigating the negative effects associated
nentially and has been shown to be associ- with AKI, mainstays of therapy include prevention
ated with worse outcomes in hospitalized patients and supportive care. Unfortunately, this management
From the *Center for Acu