左乙拉西坦递增疗法对局灶性癫痫患儿脑神经递质及睡眠结构的影响.pdf

实用医院临床杂志 年 月第 卷第 期
156 　 acetam step-up therapy on brain neurotransmitters and sleep structure in
children with focal epilepsy ZHANG Xiao-juna XU Jian-fangb a. Department of Pharmacy b.
　 , 　 ( ,
Department of Neurology Shenzhen Children’s Hospital Shenzhen China
Abstract Objective , , 518038, )
【 】　 　 To investigate the clinical efficacy and possible mechanism of lexiacetam step-up therapy for children
Methods
with focal epilepsy. 　 Eighty-five sick children with focal epilepsy from March 2018 to June 2019 were divided into observation
n n
group ( = 43) and control group ( = 42).The control group was given sodium valproate step-up therapy while the observation group
was given lexiacetam step-up 24 weeks of therapy,clinical efficacy,cognitive function,brain neurotransmitters and sleep
Results
quality were compared between two groups. 　 The effective rate in the observation group was higher than that of control group
χ2 P
( =