雾化吸入布地奈德混悬液在AECOPD的作用.doc

雾化吸入布地奈德混悬液在AECOPD的作用.doc582
临床肺科朵志2007年6刀 第！ 2卷第6期
维普
雾化吸入布地奈德混悬裁在AECOPD的件用
谢艳萍聂霖王建春钱桂生
【摘要1目的旦劭机、对照试验比nls were randomly Jlwmled m one of thn?f Uvalmenl KPuupti, ihal i$, |i|Jl>, !'KEDt or PI^CKIKf- The BLil)卵kip rwiifwl BUD rtebkilizrd suspmaitm. by fKa^crbalion wilh 4mg every l2h. Thr PftED gmup was treatfli with 20 mg by mouth cvety 12 h and a£er a w«k waft Irvaled wiltllO mg- TSe pl&cetw was Q fie red COPunart irtaimeMl «nd UrA treated with gdrengorVc&l hurmonei. All groups writ ub*erred for 24, 48 h, 7 d and 14 dP Hcsulu Hmh Uniesortfdc mJ pnxln也Janr improved in FEV, t FaQf, PaCO! urd pH *h«i conip&red with placebo(P<0. 05 )□ TJi-e dtiTerpnce in FLV, , PaO?, PaC02 . pH between bu«i«oi)ide And pn?dFiisoL[)fir Kaa not $ig- jitficanl ( P >d 05). The occurrence of vdous adverw rvrnls in the BUO gmup were lower than the PfiED proup( P < 0L G5 ), Coiidu- sions 氐山 budnHmide and prednisolone improved obtilnjent airiliw in COlTL)palitnlii. Nrbulijed hude<H>rid? nuty be an at (amative kt uial prednistplone in the treainicni of rentfidetie exactrbalLWLs df COPD with Idwh adverse events,
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慢性阻塞性肺疾^ （ COPD）由丁贰患橋人数蚩*死亡率 髙，社会疑济负担重•是许多国家关注的问题°由T思者大多 死尸急性加重期、故急性加重期的洁疗就成为当孙之急，近年 来研究显示糖皮质激索有助于慢性阻塞性肺疾^（COPD）急 性加重期的抢疗,但由于仓井呼吸道感染及其他基础糕病,糖 皮质激素的全身应用畳到-定眼制。本实验评价糖皮质激衆 雾化治疗在C0PD急性加重期的疗效及武宙全性"
对象和方法
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