鳖甲煎丸对腹膜透析相关腹膜纤维化的影响及,机制探讨.pdf

鳖甲煎丸对腹膜透析相关腹膜纤维化的影响及,机制探讨
郑登勇 朱淑瑜 吴强
[摘要] 目的 探討鳖甲煎丸对腹膜透析（PD）小鼠腹膜纤维化的抑制作用及可能机
制。
方法 5）， and the parietal peritoneum in PD group and BJJW group was
significantly thickened（P<）. Visceral peritoneal ZO-1 protein expression
was reduced， N-cadherin protein expression was increased， and pAkt was also
significantly increased（P<）. Compared with that of the PD group， the
volume of peritoneal ultrafiltration in BJJW group was significantly
improved， and the peritoneal thickness of the parietal peritoneum decreased
（P<）. The visceral peritoneal ZO-1 protein expression increased， N-
cadherin protein expression decreased， and pAkt also significantly decreased
（all P<）. Conclusion Biejiajian pill inhibits peritoneal fibrosis， and
the regulation of epithelial to mesenchymal transition（EMT） of peritoneal
mesothelial cells from PI3K/Akt signal is one of its mechanisms.
[Key words] Biejiajian pill; Peritoneal dialysis; Peritoneal fibrosis;
Epithelial to mesenchymal transition; PI3K/Akt signal
腹膜透析（Peritoneal dialysis，PD）因为腹膜纤维化而导致超滤失败，已成为患
者退出腹膜透析的主要原因之一[1]。腹膜间皮细胞上皮-间皮细胞转分化（Epithelial-
mesenchymal transition，EMT）是腹膜透析发生腹膜纤维化的基础[2，3]。磷脂酰肌醇
3-激酶/蛋白激酶 B（Phosphatidylinositol 3-kinase/Protein kinase B，PI3K/Akt）信
号通路，可调节 PD 腹膜间皮细胞 EMT 的发生，导致腹膜纤维化的发生和发展，PI3K/A