主要组织相容性复合体_MHC_基因的研究概况_史燕.pdf

第 7 卷
第 2 期生命科学研究 Vol. 7
No . 2

2003 年 6 月 Life Science Research June 2003

主要组织相容性复合体(MHC) 基因的研究概况
史
燕, 吴孝兵, 晏
鹏, 张
方
( 安徽师范大学生命科学学院, 中国安徽芜湖
241000)
摘
要: 主要组织相容性复合体( MHC) 因其在免疫方面的重要作用而倍受免疫学家重视. 随着研究的不断深
入, 了解到 MHC 是一个高度多态的基因群, 它广泛分布于各种脊椎动物体内. MHC 除了具有免疫功能外, 还
基因的多态性是最受关注的特征, 尤其是
类基因. 根据 MHC 基因的多态性,
可以在遗传、进化、行为、保护及生态等许多方面对其进行研究. 就目前的研究情况, 在结构、功能及应用等方
面对 MHC 作了介绍.
关键词: MHC; 基因; 多态性
中图分类号: Q95
文献标识码: A 文章编号: 1007
7847( 2003) 02
0104
06
A Summary of Studies on Major plex( MHC)
and MHC Genes
SHI Yan, WU Xiao
bing, YAN Peng, ZHANG Fang
( College of Life Science , Anhui Normal University , Wuhu 241000, A nhui, China)
Abstract: The major plex ( MHC) is of great interest to immunologists for the importance of
the immunological functions. Further understanding suggests that MHC is an extended cluster of genes with
extraordinary polymorphism and the genes spread over nearly all vertebrates extensively. Besides the immunological
functions, MHC genes also play important roles in many other respects. The polymorphism of MHC genes, especially
of MHC Class
genes, is the most essential property. Based on the polymorphism, MHC genes are studied in
ics, evolution, behavior, conservation, ecology and so on. Some recent data about structure, function and
application of MHC are discussed.
Key wo