鱼腥草素钠联合亚胺培南西司他丁钠对碳青霉烯耐药鲍曼不动杆菌体外抑菌作用的研究.pdf

1 122 重庆医学2022 年4月第51卷第7期
论著•临床研究 on the growth of the CRAB strain. Results Sodium houttuyfonate had a bacteriostatic
e fect on the CRAB. The minimum inhibitory concentration (MIC) of sodium hou tuyfonate of the microdilu­
tion broth method was 1 500 — 3 500 ［ig/mL,while that of the double agar dilution method was 2 500 — 3 000
戸g/mL. The fractional inhibitory concentration index (FICI) of sodium houttuyfonate and imipenem
sodium detected by the two —,andthebacteriostaticefectshowedaaddictiveefect.
Conclusion Sodium houttuyfonate has the against effect on CRAB and has an addictive effect
withimipenemcilastatinsodium.
［Keywords］ sodium houttuyfonate; imipenem sodium； carbapenem-resistance
baumanni；addictiveefect
鲍曼不动杆菌是医院感染中重要的多重耐药细 均具有抑菌作用［3］，复方鱼腥草能抑制鲍曼不动杆菌
菌之一，其感染死亡率可达35%［1］。2019年全国细 生长［4 ］。本研究以鱼腥草挥发油中的活性成分癸酰
菌耐药监测数据显示，鲍曼不动杆菌对亚***培南和美 乙醛亚硫酸钠加成物(即鱼腥草素钠)为研究对象［3］,
罗培南的耐药率高达55. 5%和57. 1 %,并呈现多重 对鱼腥草素钠联合亚***培南西司他丁钠对碳青霉烯
耐药［2］,致使临床能选择的抗菌药物越来越少。鱼腥 耐药鲍曼不动杆菌(carbapenem resistant acineto-
草具有抗菌作