Research on Correlation Between Tigecycline-induced Hypofibrinogenemia and Concentration JIN Lu1,2,LUO Xuemei1,YANG Xiaoxuan3,ZHU Huaijun1,GE Weihong1 ( of Medication,Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008,China;2. Nanjing Medical Center for Clinical Pharmacy,Nanjing 210008,China;3. Nanjing Drum Tower Hospital of China Pharmaceutical University,Nanjing 210008,China) ABSTRACT Objective: To determine the existence of correlation between tigecycline-induced hypofibrinogenemia and concentration and define thresholds above which toxicity is more likely. Methods: Patients receiving tigecycline from April 2019 to April 2021 were retrospectively analyzed, andthe concentration of tigecycline, fibrinogen(FIB)values and other clinical indicators were recorded before and after treatment, and the patients were classified into adverse drug reaction(ADR)group and control group according to the criteria. The difference in tigecycline concentration between the two groups was analyzed and the cut-off of ADR was obtained by ROC : 123 patients were enrolled according to the criteria, and there was no statistical difference in age, gender, dose, course of treatment and other clinical characteristics between ADR group and control group. There were significant differences in tigecy