1234 临床肝胆病杂志第 38 卷第 6 期 2022 年 6 月 J Clin Hepatol,Vol.38 No.6,Jun.2022 ·专家论坛· ypertension. HSOS in China is mostly associated with the intake of pyrrolizidine alkaloids. The step - up approach with anticoagulant � � therapy and transjugular intrahepatic portosystemic shunt TIPS as the core treatment methods is the therapy currently recommended for this , disease. Subcutaneous injection of low - molecular - weight heparin is the first choice for anticoagulant therapy and oral warfarin can be used in combination or sequentially to enhance anticoagulation. Patients with no response to anticoagulant therapy can switch to TIPS. The � � , Drum Tower Severity Score DTSS system can be used during treatment to evaluate the severity of the disease in order to identify high - , risk patients earlier and switch to TIPS in time thereby improving the prognosis of patients. � � � �