热休克蛋白90AB1在肝细胞癌中的表达及初步验证.pdf

汕头大学医学院学报
第34卷 第2期 Journal of Shantou University Medical College
2021年6月 General Surgery the First Affiliated Hospital of Shantou University Medical College Shantou 515041 China)
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To investigate the expression significance of heat shock protein 90 kDa alpha, class B
[Abstract] Objective:
member 1 (Hsp90AB1) in hepatocellular carcinoma (HCC). The immunohistochemical staining method
Methods:
was used to detect the expression of Hsp90AB1 in HCC tissue chip. Bioinformatics analysis technology was used
to analyze the HCC related gene chip GSE54238; the expression of gene in normal liver tissues and
Hsp90AB1
HCC tissues were analyzed using the database GEPIA, and the survival analysis of HCC patients based on the
expression difference of Hsp90AB1 was performed. qRT-PCR was used to detect the expression of
Hsp90AB1
gene in normal liver cell lines and liver cancer cell lines. Immunohistochemical experiment showed that
Results:
Hsp90AB1 was up-regulated in HCC tissues compared with normal liver tissues ( <