牡荆葡基黄酮对肺癌细胞恶性生物学行为及肿瘤生长的影响.pdf

广 东 药 科 大 学 学 报
Jan. 2021,37(1)
文献标识码： 文章编号：
DOI: ‐⁃‑3653. 2020102303
Effects of Vitexin on malignant biological behavior and tumor growth of lung
cancer cells
CHEN Hongyun*, LI Xiaoming, HUANG Guosheng, YANG Jinhua, QIAO Fei
(
Department of General Thoracic Surgery, the First Affiliated Hospital of Nanyang Medical College,
473000 )
Nanyang , China
Email: chenhongyun_******@
*Corresponding author
To explore the regulatory role of Vitexin in invasion and migration, microtubule
Abstract: Objective
formation, mesenchymal transition and tumor growth of lung cancer cells. Lung cancer A549
Methods
cells were cultured and treated with Vitexin at different concentrations for 24 h. CCK8 was used to
in vitro
select the appropriate dose of Vitexin. Transwell and scratch test were used to detect the invasion and
migration of lung cancer cells. Tube formation test was used to detect the number of microtubules.
Western blot was used to detect the expression of ‐⁃‑cadherin, ‐⁃‑cadherin and fibronectin (FN). The nude