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神经嵴细胞和轴突的特异性课件.ppt


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该【神经嵴细胞和轴突的特异性课件 】是由【012luyin】上传分享,文档一共【27】页,该文档可以免费在线阅读,需要了解更多关于【神经嵴细胞和轴突的特异性课件 】的内容,可以使用淘豆网的站内搜索功能,选择自己适合的文档,以下文字是截取该文章内的部分文字,如需要获得完整电子版,请下载此文档到您的设备,方便您编辑和打印。Neuralcrestcellsandaxonalspecificity
Theneuralcrestandsomederivativesoftheneuralcrest
Theneuralcrestcanbedividedintofourmainfunctionaldomains
Thetrunkneuralcrest
Thecranial(面部)neuralcrest
Thecardiac(心区)neuralcrest
Thevagal(迷走)andsacral(尾底)neuralcrest
Theneuralcrestcellsoriginateatthedorsalmostregionoftheneuraltube
Theneuralcrestcellsgenerateanumberofdifferentiatedcelltypes
theneuronsandglialcells(胶质细胞)ofthesensory,sympathetic,andparasympatheticnervoussystems
theepinephrine-producing(medulla)cellsoftheadrenalgland(肾上腺髓质细胞)
thepigment-containingcellsoftheepidermis
manyoftheskeletalandconnectivetissuecomponentsofthehead.

Peripheralnervoussystem(PNS)(外周神经系统):includingsensoryganglia,sympatheticandparasympatheticganglia,Schwanncells(雪旺细胞),Neuroglialcells.
Endocrineandparaendocrinederivatives(内分泌和旁分泌组织):Calcitonin-secretingcells(降血钙素分泌细胞),CarotidbodytypeIcells(颈动脉一型体细胞).
Pigmentcells(色素细胞):Epidermalpigmentcells.
Facialcartilageandbone(面部的骨骼和骨组织):Facialandanteriorventralskullcartilageandbones.
Connectivetissue(结缔组织):Cornealendotheliumandstroma,Toothpapillae,Dermis,smoothmuscle,andadiposetissueofskinofheadandneck,Connectivetissueofsalivary,lachrymal,thymus,thyroid,andpituitaryglands,Connectivetissueandsmoothmuscleinarteriesofaorticarchorigin.`
Thetrunkneuralcrest
Themechanismsoftrunkneuralcrestmigration
?
?
?
Theneuralcrestcellmigration
Neuralcrestcellsoriginatefromtheneuralfoldsthroughinteractionsoftheneuralplatewiththepresumptiveepidermis.
Inculturesofembryonicchickectoderm,(骨形态发生蛋白)4and7(BMP4andBMP7),twoproteinsthatareknowntobesecretedbythepresumptiveepidermis.
BMP4andBMP7inducetheexpressionoftheSlugproteinandtheRhoBproteininthecellsdestinedtobecomeneuralcrest
TheRhoBproteinmaybeinvolvedinestablishingthecytoskeletalconditionsthatpromotemigration.
TheSlugproteinistoactivatethefactorsthatdissociatethetightjunctionsbetweenthecells.
N-,buttheybegintoexpressitagainastheyaggregatetoformthedorsalrootandsympatheticganglia.
Recognitionofsurroundingextracellularmatrices
Theextracellularmatrixmoleculesthatenableorforbidmigration.(这两类分子通过不同区域分布确定迁移路线)
Theseproteinspromotesmigrationincludefibronectin,laminin,variouscollagenmolecules(胶原分子),andproteoglycans蛋白聚糖.
Anotherproteinsimpedesmigration(theephrinproteins).
Theseproteinsareexpressedintheposteriorsectionofeachsclerotome,andwherevertheyare,(酪氨酸激酶).
Segmentalrestrictionofneural crestcellsandmotorneuronsbytheephrinproteinsofthesclerotome.(A)Negativecorrelationbetweenregionsofephrininthesclerotome(darkbluestain,left)andneuralcrestcellmigration(greenHNK-1stain,right).(B)Whenneuralcrestcellsareplatedonfibronectin-containingmatriceswithalternatingstripesofephrin,theybindtothoseregionslackingephrin.(C)Compositeschemeshowingmigrationofspinalcordneuralcrestcellsandmotorneuronsthroughtheephrin-deficientanteriorregionsofthesclerotomes.(Forclarity,theneuralcrestcellsandmotorneuronsareeachdepictedononlyonesideofthespinalcord
Pluripotencyoftrunkneuralcrestcells.(A)Asingleneuralcrestcellis injectedwithhighlyfluorescentdextran(荧光右旋糖酐).(B)Twodayslater,neuralcrest-derivedtissuescontaindextran-(case1andcase2).

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  • 时间2022-11-29