该【有机质谱中科院 】是由【我是药神】上传分享,文档一共【264】页,该文档可以免费在线阅读,需要了解更多关于【有机质谱中科院 】的内容,可以使用淘豆网的站内搜索功能,选择自己适合的文档,以下文字是截取该文章内的部分文字,如需要获得完整电子版,请下载此文档到您的设备,方便您编辑和打印。有机质谱中科院
(1877-1945)
CambridgeUniversityCambridge,GreatBritain
TheNobelPrizeinChemistry1922
"forhisdiscovery,bymeansofhis
massspectrograph,ofisotopes,ina
largenumberofnon-radioactive
elements,andforhisenunciationof
thewhole-numberrule"
massspectrometryofisotopes
NobelLaureate(1922):FrancisWilliamAston
(1913-1993)
UniversityofBonnBonn,Germany
TheNobelPrizeinPhysics1989
“Forthedevelopmentoftheiontrap
technique"
Quadrupoleand
Quadrupoleiontrapmassspectrometers
NobelLaureate(1989):WolfgangPaul
(1917)
VirginiaCommonwealthUniversityRichmond,Virginia
TheNobelPrizeinChemistry2019
"forthedevelopmentofsoftdesorptionionisationmethodsformassspectrometricanalysesofbiologicalmacromolecules"
Electrosprayionizationofbiomolecules
NobelLaureate(2019):
1989-ESIofBiomolecules
“TheapplicationofESItobiomoleculeswasoneofthemostimportantdiscoveriesinmassspectrometryinthelatterpartofthetwentiethcentury.”
(1959-)
ShimadzuCorporation
TheNobelPrizeinChemistry2019
"forthedevelopmentofsoftdesorptionionisationmethodsformassspectrometricanalysesofbiologicalmacromolecules"
Matrix-assistedlaserdesorption/ionization(MALDI)
NobelLaureate(2019):KoichiTanaka
(1923)
CornellUniversity,Ithaca,NewYork
AMSpioneeringaseousionreactions(theMcLaffertyrearrangement),
instrumentation(GC/MS,LC/MS,MS/MS),
techniques(collisionallyactivateddissociation,neutralization-reionization,
electroncapturedissociation,IRphotodissociationspectroscopy)
computerdataacquisition,reduction,andidentification(ProbabilityBasedMatching),
referencedata(600Kspectra),and
highresolutionMS/MScharacterizationofbiomoleculesandgas-phaseproteinconformers.
Innovators
UniversityofMaryland
NotableAchievements
BiomedicalApplicationsofMassSpectrometry
MechanismsofAcquiredDrugResistance
RapidAnalysisofIntactMicroorganismsbyMassSpectrometry
(1941-)
DepartmentofChemistry,PurdueUniversityWestLafayette,Indiana
Mixtureanalysisbytandemmassspectrometry
Kineticmethodformeasuringionthermochemistry
Surfaceinduceddissociationandion/surfacereactions
Hybridmassspectrometers
Energypartitioninginiondissociation
Matrix-assisteddesorption/ionization
Iontraps:simulationsofionmotion,miniaturization
质谱是重要的分析工具,应用相当广泛,其特点可以概括为:
Sensitivity
Speed
Specificity
Stoichiometry
质谱法与其他主要分析方法灵敏度的比较
分析方法
检测灵敏度(g)
NMR
10-3~10-5
IR
10-6~10-7
GC
10-6~10-13
UV
10-6~10-7
MS
10-11~10-12
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